https://notebooklm.google.com/notebook/c766a406-f45d-499a-b17f-ac0f9507d366/audio
This study investigates the impact of curcumin on colon cancer patients’ immune response. Researchers found that curcumin administration reduces regulatory T cells (Tregs) and increases T helper 1 cells (Th1). The mechanism involves curcumin suppressing Foxp3 expression in Tregs, converting them into Th1 cells. Further investigation showed that Foxp3 binds to T-bet, preventing IFN-γ expression, but curcumin disrupts this interaction. These findings suggest curcumin may regulate tumor tolerance by modulating Tregs and enhancing antitumor immunity. Ultimately, curcumin’s ability to shift the balance towards Th1 cells could contribute to its therapeutic effects in colon cancer.
