Curcumin Attenuates Oxidative Stress via Nrf2-Keap1 Pathway in Macrophages
https://notebooklm.google.com/notebook/a1b48149-acd1-4bb6-9cd9-8a9a4c1b575e/audio
This study investigated the antioxidant effects of curcumin on macrophages subjected to oxidative stress. Researchers used RAW264.7 cells, inducing oxidative damage with hydrogen peroxide, and then observed the effects of different curcumin concentrations. The study focused on the Nrf2-Keap1 signaling pathway, a key regulator of cellular stress responses. Results indicated that low to middle doses of curcumin increased antioxidant enzyme activity, reduced reactive oxygen species, and activated Nrf2, promoting cell survival. High doses of curcumin, however, intensified oxidative stress, suggesting a dose-dependent effect. Overall, the research suggests curcumin can protect macrophages from oxidative damage by modulating antioxidant pathways.
